Rob Striker Lab
University of Wisconsin – Madison

Publications

Recent Striker lab CD4/CD8 ratio papers

  1. McBride JA, Striker R. Imbalance in the game of T cells: What can the CD4/CD8 T-cell ratio tell us about HIV and health? PLoS Pathog. 2017 Nov 2;13(11):e1006624. doi: 10.1371/journal.ppat.1006624. PMID: 29095912; PMCID: PMC5667733.
  2. Gergen M, Hewitt A, Sanger CB, Striker R. Monitoring immune recovery on HIV therapy: critical, helpful, or waste of money in the current era? AIDS. 2024 Feb 2. doi: 10.1097/QAD.0000000000003850. Epub ahead of print. PMID: 38310348.
  3. Karim A, Freeman MJ, Yang Q, Leverson G, Cherney-Stafford L, Striker R, Sanger CB. Duration of Time CD4/CD8 Ratio is Below 0.5 is Associated with Progression to Anal Cancer in Patients with HIV and High-Grade Dysplasia. Ann Surg Oncol. 2023 Aug;30(8):4737-4743. doi: 10.1245/s10434-023-13213-z. Epub 2023 Mar 4. PMID: 36869915.
  4. Wolday D, Legesse D, Kebede Y, Siraj DS, McBride JA, Striker R. Immune recovery in HIV-1 infected patients with sustained viral suppression under long-term antiretroviral therapy in Ethiopia. PLoS One. 2020 Oct 22;15(10):e0240880. doi: 10.1371/journal.pone.0240880. PMID: 33091053; PMCID: PMC7580989.
  5. Wolday D, Kebede Y, Legesse D, Siraj DS, McBride JA, Kirsch MJ, Striker R. Role of CD4/CD8 ratio on the incidence of tuberculosis in HIV-infected patients on antiretroviral therapy followed up for more than a decade. PLoS One. 2020 May 22;15(5):e0233049. doi: 10.1371/journal.pone.0233049. PMID: 32442166; PMCID: PMC7244128.

Selected ratio papers from other groups

  1. Ahuja, S. K. et al. Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection. Nat. Commun. 14, 3286 (2023).
  2. Serrano-Villar, S. et al. HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality. PLoS Pathog. 10, e1004078 (2014).3.
  3. Castilho, J. L. et al. CD4/CD8 Ratio and Cancer Risk Among Adults With HIV. J. Natl. Cancer Inst. 114, 854–862 (2022).
  4. Chammartin, F. et. al., Measures of Longitudinal Immune Dysfunction and Risk of AIDS and Non-AIDS Defining Malignancies in Antiretroviral-Treated People With Human Immunodeficiency Virus
    Clinical Infectious Diseases, Volume 78, Issue 4, 15 April 2024, Pages 995–1004, https://doi.org/10.1093/cid/ciad671