Selected bacterial kinase papers
Wlodarchak N, Teachout N, Beczkiewicz J, Procknow R, Schaenzer A, Satyshur K, Pavelka M, Zuercher B, Drewry D, Sauer JD, Striker R. In Silico Screen and Structural Analysis Identifies Bacterial Kinase Inhibitors which Act with β-Lactams To Inhibit Mycobacterial Growth. 2018 Mol. Pharmaceutics 15 (11), pp 5410–5426. Available from https://doi.org/10.1021/acs.molpharmaceut.8b00905
Schaenzer AJ, Wlodarchak N, Drewry DH, Zuercher WJ, Rose WE, Striker R, Sauer JD. A small molecule screen identifies inhibitors of the PASTA kinase PrkA, an essential Listeria monocytogenes virulence factor. 2017 Journal of Biological Chemistry. Epub ahead of print DOI: 10.1074/jbc.M117.808600
Pensinger D, Schaenzer A, & Sauer JD. Do Shoot the Messenger: PASTA Kinases as Virulence Determinants and Antibiotic Targets. 2017 Trends in Microbiology, 0(0). doi:10.1016/j.tim.2017.06.010
Pensinger DA, Boldon KM, Chen GY, Vincent WJB, Sherman K, Xiong M, Striker R, Sauer JD. The Listeria monocytogenes PASTA Kinase PrkA and Its Substrate YvcK Are Required for Cell Wall Homeostasis, Metabolism, and Virulence. 2016 PLoS Pathog 12(11):e1006001.
Wlodarchak N, Tariq R, Striker R. Comparative analysis of the human and zebrafish kinomes: focus on kinase inhibitor development. 2015 Trends in Pharmacological Sciences. 10:49-75. PMID: 27011661
Pensinger DA, Schnauzer A, Boldon K, Aliota MT, Ansari IH, Knight B, Reniere ML, Striker R, Sauer JD. Selective Pharmacologic Inhibition of a PASTA Kinase Increases Listeria monocytogenes Susceptibility to β-lactam antibiotics. 2014 Antimicrobial Agents and Chemotherapy 58(8):4486–94.
Selected viral kinase papers
Keating J, Bhattacharya D, Rund SC, Das Gupta R, Lee SJ, Duffield GE, Hoover S, Striker R. Mosquito protein kinase G phosphorylates flavivirus NS5 and alters flight behavior in Aedes aegypti and Anopheles gambiae. 2013 Vector Borne Zoonotic Dis. 13(8):590–600. PMID: 23930976. PMCID: PMC3741427.
Bhattacharya D, Ansari IH, Striker R. The flaviviral methyltransferase is a substrate of Casein Kinase 1. 2009 Virus Res 141(1):101–4.
Bhattacharya D, Mayuri KR, Striker R. Protein Kinase G phosphorylates mosquito borne flaviviruses. 2009 J Virol 83(18):9195–205. PMC2738234
Bhattacharya D, Hoover S, White S, Vestling M, Weisblum B, Striker R. Flaviviral NS5 Phosphorylation can regulate viral methyl transferase activity. 2008 Virology 380:276–284.
Other selected papers repurposing kinase inhibitors as anti-infectives
Klug DM, Gelb MH, Pollastri MP. Repurposing strategies for tropical disease drug discovery. 2016 Bioorg Med Chem Lett 26(11):2569-76. doi: 10.1016/j.bmcl.2016.03.103
Turapov O, Loraine J, Jenkins CH, Barthe P, McFeely D, Forti F, Ghisotti D, Hesek D, Lee M, Bottrill AR, Vollmer W, Mobashery S, Cohen-Gonsaud M, and Mukamolova GV. The external PASTA domain of the essential serine/threonine protein kinase PknB regulates mycobacterial growth. 2015 Open Biol 5, 150025
Vornhagen J, Burnside K, Whidbey C, Berry J, Qin X, and Rajagopal L. Kinase Inhibitors that Increase the Sensitivity of Methicillin Resistant Staphylococcus aureus to beta-Lactam Antibiotics. 2015 Pathogens 4, 708-721
Wright DP and Ulijasz AT. Regulation of transcription by eukaryotic-like serine-threonine kinases and phosphatases in Gram-positive bacterial pathogens. 2014 Virulence 5, 863-885
Reynolds RC, Ananthan S, Faaleolea E, Hobrath JV, Kwong CD, Maddox C, Rasmussen L, Sosa MI, Thammasuvimol E, White EL, Zhang W, and Secrist JA. High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37Rv. 2012 Tuberculosis (Edinb) 92, 72-83
Lougheed, K. E.; Osborne, S. A.; Saxty, B.; Whalley, D.; Chapman, T.; Bouloc, N.; Chugh, J.; Nott, T. J.; Patel, D.; Spivey, V. L.; Kettleborough, C. A.; Bryans, J. S.; Taylor, D. L.; Smerdon, S. J.; Buxton, R. S., Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents. 2011 Tuberculosis (Edinb) 91 (4), 277-86.